Release 25.2 - August 2025

We are excited to introduce several significant enhancements in our latest release, designed to enhance user experience and functionality.

• Redesigned reaction cards with a more information-rich layout, providing improved usability and clarity.
• Comprehensive list of reactions with clearer identification of reaction type (predicted or published) and source database.
• Detailed reaction conditions, including typical conditions for predicted reactions and experimental conditions for published reactions.
• Seamless addition of reagents and solvents directly to the shopping list.
• Access to experimental procedures for reactions sourced from patents.

• Newly introduced molecule cards featuring a layout consistent with the reaction cards.
• Improved design offering more detailed and easily accessible information about molecules. 

1102 new expert rules have been added, including rules for:

• Acid-catalyzed carbocyclization of alkynols
• Acylation of sultams
• Addition of imides to alkenes
• Alpha-iodination reaction
• Aluminium-catalyzed stereoselective acyloin rearrangement
• Asymmetric hydrogenation of exocyclic alpha,beta-unsaturated nitriles
• Bimetallic-relay-catalyzed dynamic kinetic asymmetric aminoboration of alkenes
• Bimetallic-relay-catalyzed dynamic kinetic asymmetric aminoboration of alkenes followed by oxidation of boronate
• Bimetallic-relay-catalyzed dynamic kinetic asymmetric aminoboration of alkenes followed by oxidation of boronate and debenzylationBoc deprotection reaction
• Boron-mediated intramolecular aldol condensation
• Boron-mediated stereoselective intramolecular aldol condensation
• Bronsted acid-promoted intramolecular carbocyclization of alkynals
• Chromium-catalyzed cross-coupling of ketones
• Cobalt-catalyzed stereoselective aldol cycloreduction
• Cobalt-catalyzed stereoselective Michael cycloreduction
• Cobalt-catalyzed stereoselective reductive [3 + 2] cycloaddition of allenes and enones
• Cobalt-catalyzed three-component alkyl arylation of acrylates
• Copper-catalyzed asymmetric allylic C-H oxidation of terminal alkenes
• Copper-catalyzed asymmetric allylic C-H oxidation of terminal alkenes followed by ester hydrolysis
• Copper-catalyzed intramolecular annulation of acetylenic halides
• Copper-catalyzed intramolecular reductive aldol condensation
• Copper-catalyzed oxidative allylic C-H arylation of alkenes with (hetero)aryl boronic acids
• Copper-catalyzed stereoselective allylic alkylation with Grignard reagents
• Copper-catalyzed stereoselective aminoboration of Z-alkenes
• Copper-catalyzed stereoselective aminoboration of Z-alkenes followed by oxidation of boronate
• Copper-catalyzed stereoselective aminoboration of Z-alkenes followed by oxidation of boronate and debenzylation
• Copper-catalyzed stereoselective reductive aldol cyclization
• Copper-catalyzed steroselective three-component radical carboamidation of styrenes with alkanes and amides
• Copper-catalyzed steroselective three-component radical carboamidation of styrenes with alkanes and amides followed by amide hydrolysis
• Corey-Seebach reaction followed by cleavage of 1,3-dithiane
• Cross-dehydrogenative coupling of hydrosilanes and alcohols
• Curtius rearrangement
• Cyclization of alpha,beta-unsaturated alpha-diketones
  
• Cyclopropanation on silyl enol ethers
• Cyclopropanation on silyl enol ethers followed by deprotection
• Dihydroxylation of alkenes
• Direct Tiffeneau-Demjanov-type ring expansion reaction
• Gallium-catalyzed tandem carbonyl-olefin metathesis transfer hydrogenation reaction
• Intramolecular aldol reaction
• Intramolecular Corey-Chaykovsky epoxidation
• Intramolecular cyclopropanation of terminal epoxides
• Intramolecular Morita-Baylis-hillman reaction
• Intramolecular pinacol coupling reaction
• Intramolecular [2+2] photocycloadditions
• Iridium-catalyzed C-H alkenylation of secondary alcohols
• Iron-catalyzed cross coupling of alkenyl aryl carboxylates with Grignard reagents
• Iron-mediated segment coupling via carbon-to-carbon radical translocation and remote oxidative hydrogen atom transfer
• Ni-catalyzed synthesis of enones from acid fluorides and vinyl triflates
• Nickel-catalyzed allenyl aldehyde cyclization
• Nickel-catalyzed asymmetric reductive cross-coupling of alpha-iodoacetals with aryl halides
• Nickel-catalyzed asymmetric reductive cross-coupling of alpha-iodoacetals with aryl halides followed by deprotection
• Nickel-catalyzed decarboxylative alkenylation of aliphatic anhydrides
• Nickel-catalyzed hydrocyanation of alkynylhalides
• Nickel-catalyzed Negishi alkylations of styrenyl aziridines
• Nickel-catalyzed Negishi cross-coupling of 1,1-disubstituted styrenyl with organozinc derivatives
• Nickel-catalyzed reductive cross-coupling of aziridines and allylic chlorides
• Nickel-catalyzed reductive cross-coupling of aziridines and allylic chlorides followed by detosylation
• Nickel-catalyzed regioselective functionalization of olefins via tandem cyclization cross-coupling reaction
• Nickel-catalyzed stereoselective radical relayed reductive coupling
• Nickel-catalyzed stereoselective radical relayed reductive coupling followed by amide hydrolysis
• Nickel-catalyzed stereospecific intramolecular Heck reaction
• Nickel-catalyzed [2+1+1+1] cycloaddition reaction
• One-carbon homologation of alkenes via cross-metathesis retro-ene one-pot reaction sequence
• Organocatalytic [3+2] cycloaddition of cyclopropanes with alkenes
• Palladium-catalyzed arylation of allylic benzoates
• Palladium-catalyzed difunctionalization of norbornenes via arylation and alkynylation
• Palladium-catalyzed enatioselective [3+2] cycloaddition of trimethylenemethane with nitroalkenes
• Palladium-catalyzed intramolecular addition of 1,3-diones to unactivated olefins
• Palladium-catalyzed intramolecular oxidative alkylation of unactivated alkenes
• Palladium-catalyzed oxidative cyclization reaction
• Palladium-catalyzed silylation of aryl halides
• Palladium-catalyzed steroselective [3+2] cycloaddition of trimethylenemethane with nitroalkenes
• Photo- and copper-catalyzed stereoselective benzylic C-H oxidation
• Photo- and copper-catalyzed stereoselective benzylic C-H oxidation followed by cleavage of N-O bond
• Photo- and copper-catalyzed stereoselective benzylic C-H oxidation followed by hydrazinolysis of phthalimide
• Photocatalytic alkylazolation of alkenes via a radical-polar crossover
• Photocatalytic ring-expansion of cyclopropanes via proton-coupled electron transfer
• Preparation of 1-(2-methyoxyethoxy)-1-vinylcyclopropane
• Preparation of 1-ethoxy-1-(trimethylsilyloxy)cyclopropane
• Preparation of 1-ethoxy-1-hydroxycyclopropane
• Preparation of 2-(2-methyoxyethoxy)-1,3-butadiene
• Preparation of tert-butyl vinyl carbamate
• Regioselective synthesis of arylethylamines via photocatalytic radical hydroarylation of vinyl amine derivatives
• Rhenium-catalyzed ring-expansion reaction
• Rhodium-catalyzed asymmetric hydroamination of alkenes
• Rhodium-catalyzed asymmetric hydroamination of alkenes followed by selective deprotection
• Rhodium-catalyzed asymmetric hydroamination of alkenes followed by selective hydrolysis
• Rhodium-catalyzed asymmetric hydroformylation reaction
• Rhodium-catalyzed carbofunctionalization of terminal alkynes
• Rhodium-catalyzed dehomologative borylation
• Rhodium-catalyzed dehomologative borylation followed by hydrogenation
• Rhodium-catalyzed hydrogenative aldol condensation
• Rhodium-catalyzed intermolecular [5+2] cycloaddition of vinylcyclopropanes and ynol ethers
• Rhodium-catalyzed stereoselective C-H insertion of azavinyl carbenes into unactivated alkanes
• Rhodium-catalyzed stereoselective cyclopropanation of acetylenes
• Rhodium-catalyzed [5+2] cycloaddition of vinylcyclopropanes and alkynes
• Samarium-catalyzed cyclization of 1,5-dienes via borylation oxidation sequence
• Scandium-catalyzed synthesis of cyclobutene derivatives via [2+2] annulation of alkynylnaphthols with dienes
• Selective dehydration of tertiary alcohol
• Silver-catalyzed intermolecular carbonyl olefination reaction
• Simultaneous hydrogenation of alkenes and debenzylation
• Simultaneous stereoselective hydrogenation of alkenes and debenzylation
• Stereoconvergent alkyl-alkyl suzuki cross-coupling of unactivated electrophiles
• Stereoselective Conia-ene reaction
• Stereoselective domino heck arylation and alkylation of dienes
• Stereoselective domino heck arylation and alkylation of dienes followed by decarboxylation
• Stereoselective intramolecular aldol reaction
• Stereoselective opening of epoxides with Grignard reagents
• Stereoselective synthesis of 1,3-cycloheptanediones cope rearrangement of cis-divinylcyclopropanes
• Stereoselective synthesis of cyclopentanes via relay ring-closing methatesis and organocatalytic Michael addition
• Stereospecific and regioselective suzuki-miyaura arylation of 2-arylaziridines
• Synthesis of iminosulfur difluorides
• Synthesis of arylsiloxanes
• Synthesis of benzothiadiazoles
• Synthesis of bis-sulfonyl sulfur diimides
• Synthesis of boc-protected sultams
• Synthesis of branched amines via opening of aziridines with organotrifluoroborates
• Synthesis of dicyano-2-methylenebut-3-enoates
• Synthesis of N-vinyl aryl amides
• Synthesis of sulfur diimides
• Synthesis of tetralins via skeletal editing of isoindolines
• Synthesis of vinyl triflates
• Tandem deamination aldol condensation of tropinone derivatives
• Tandem double Michael addition Dieckmann condensation reaction
• Titanium-catalyzed steroselective formal [3+2] cycloaddition of cyclopropyl ketones and alkenes

Version 25.2 of SYNTHIA™ has been tested with Chrome versions 139.0.7258.66, 139.0.7258.128 and 139.0.7258.129 on Windows 11 Enterprise, and Mac OS Sequoia 15.6.