Release 6.4 - August 2022

We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed.

• New Analysis Parameters – Exclude reactions using gaseous reagents and/or transition metal-based catalysts from your results
• Login Page – Login with your email address, check ‘Remember me’ to have it auto-filled next time you open your application
• Inventory Managers – Download the hashing tool for your inventory compounds file directly from your SYNTHIA™ application

• Improved keyword filter for analysis results
• Enhanced 'Promote Robust Reactions' setting
• Updated price information for commercial compounds available in solution

4200 new expert rules have been added, covering reactions such as:

• Synthesis of 1-Substituted 1,2,3-Triazoles
• Metal-free Synthesis of 1-Substituted-1,2,3-Triazoles
• Copper-Catalyzed Synthesis of 1,2,4-triazoles
• Synthesis of [1,2,4]Triazolo[1,5-a]pyridin-2-amines
• Aromatic Nucleophilic Substitution of Nitroanilines
• Asymmetric Synthesis of Protected Unnatural Alpha-Amino Acids
• Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis
• Cycloaddition of Propargylamines with Dialkyl Azodicarboxylates
• Decarboxylative Halogenations of Carboxylic Acids
• Visible-light-induced Decarboxylative Iodination of Aromatic Carboxylic Acids
• Glycosylation of Alcohols
• Schmidt Glycosylation
• 1,3-Directed Metalations Followed by Reactions with Electrophiles
• Protodecarboxylation of 1-Aryl-4-fluoroalkyl-1,2,3-triazoles-5-carboxylic Acids
• Radical Hydroxymethylation of Alkyl Iodides
• Rhodium-Catalyzed Regio- and Enantioselective Allylic Amination of Racemic 1,2-Disubstituted Allylic Phosphates
• Silver-mediated Synthesis of 3-Substituted Pyrazoles
• Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines
• Synthesis of Aromatic Azoxy Compounds from Anilines
• Synthesis of Azadipyrromethenes
• Asymmetric Aza-Baylis-Hillman Reaction
• Formylation Of Alcohols, Amines, Thiols
• Intramolecular Tishchenko Reaction
• Ru-Catalyzed Stereoselective Synthesis of Aldehydes from Alkenes
• Ni-Catalyzed Stereo- and Regioselective Alkylboration of Endocyclic Olefins
• Synthesis of Symmetrical Disiloxanes

The database of commercial compounds has been updated, to include:

• 9 532 new compounds
• 4.48 million updated compounds
• For a total of 17,560,130 published compounds, including 6,848,931 commercial compounds

Version 6.4.0 of SYNTHIA™ has been tested with Chrome version 101.0.4951.67, 102.0.5005.115 and 103.0.5060.114, and Microsoft Edge version 103.0.1264.51 and 98.0.1108.51 on Windows 10 version 19042, and Mac OS Monterey 12.4.