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Learning Center
Release 6.2 - October 2021
We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed.
What’s New
- Promote robust reactions in your results by enabling the new Robustness option in your analysis parameters
- Appoint an internal Account Manager to check user status, unlock users, or delete user accounts for your organization
Fixes and Improvements
- Improved performance decreases analyses run time
Chemistry
230 new expert rules have been added, covering reactions such as:
- Buchwald-Hartwig amination of nitroarenes
- Palladium-catalyzed denitrative Sonogashira-type cross-coupling of nitrobenzenes with terminal alkynes
- Diastereoselective Palladium-catalyzed hydrogenation of fluoropyridines
- Rhodium-catalyzed enantioselective hydroformylation of alkenes
- Intramolecular Copper-catalyzed Buchwald-Hartwig reaction
- Light-promoted stereoselective synthesis of unnatural alpha-amino acid derivatives
- Palladium-catalyzed hydrogenation of fluoropyridines and fluoroimidazopyridines
- Palladium-catalyzed Mizoroki-Heck reaction of nitroarenes and styrene derivatives
- Ritter reaction
- Stereospecific Suzuki-Miyaura cross-coupling forming diaryl quaternary stereocenters
- Suzuki-Miyaura coupling of nitroarenes
- Transition metal-catalyzed denitrative thioetherification of alkyl halides and arylboronic acids with nitroarenes
- Transition metal-catalyzed denitrative etherification of nitroarenes
- Transition metal-catalyzed denitrative methylation of nitroarenes
Databases
The database of commercial compounds has been updated, to include:
- 229,355 new compounds
- 4.78 million updated compounds
- For a total of 17,392,316 published compounds, including 7,014,712 commercial compounds
Version 6.2.0 of SYNTHIA™ has been tested with Chrome version 93.0.4577.82, 91.0.4472.124 and 91.0.4472.124 on Windows 10 version 1909, and Mac OS Catalina 10.15.7 and Big Sur 11.4 and 11.5.2.
