Release 6.1 - July 2021

We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed.

• Explore chemistry around specific disconnections of your target molecule by designating a specific bond to be cut
• Use our new shortcuts in the molecule editor to define either retrosynthetic cuts you want to make or bonds you want to preserve
• Filter your manual retrosynthesis analysis results to remove unwanted reactions or focus on interesting intermediates

• Inventory compound information exported in pdf reports
• Support added for non-Latin characters in pdf reports
• Similar reaction suggestions improved

1260 new expert rules have been added, covering reactions such as:

• Asymmetric hydrogenation of flavones, chromones, cyclic imines and enamines
• Asymmetric reduction of various aromatic systems, such as pyrroles, furans, thiophenes, indoles, indolines, benzofurans, benzothiophenes, imidazoles, oxazoles, quinolines, isoquinolines, quinoxalines, quinoxalinones, N-iminopyridinium ylides, pyridines or pyrazines
• Enantioselective Simmons-Smith cyclopropanation
• Condensation of hydrazides with aryl nitriles
• Synthesis of dihydropyrazines
• O-phosphination of aldehydes
• Oxidative cross-coupling of trialkyl phosphites with thiophenols
• Oxidative cross-coupling of aryl-alkyl ketones with H-phosphonates and H-phosphine oxides
• Partial reduction of pyrroles
• Pinner reaction
• Synthesis of alkyl amidrazones from alkyl nitriles
• Catalytic metal-free phosphorylation of amines and alcohols

Version 6.1.0 of SYNTHIA™ has been tested with Chrome version 91.0.4472.114 and 91.0.4472.124 on Windows 10 version 1909, and Mac OS Catalina 10.15.7 and Big Sur 11.4