Release 24.0 - January 2024

We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed with this latest release.

• New Published Reaction Database: Science of Synthesis provides full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, that review synthetic methodology developed from the early 1800s to-date for the entire field of organic and organometallic chemistry. World-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations.

265 new expert rules have been added, including rules for:

• Azide-nitrile cycloaddition
• Aminoboration of unactivated alkenes
• Bromination of porphyrin meso positions
• Difluoromethylation of aryl iodides 
• Direct electrophilic monofluoromethylation of nucleophiles
• Functionalizations of pyridine N-oxides
• Hydrofluoroalkylation of alkenes
• Ipso-selective nitrene internalization
• Nucleophilic aromatic substitution
• [2+2]-Cycloadditions of dioxaborole with alkenes followed by oxidation
• Preparation of dioxaboroles
• Regioselective 1,1-difluorination of enynes
• Synthesis of 1,2,4-oxadiazol-5-ols
• Synthesis of alpha-fluorinated carboxylic acid derivatives
• Synthesis of cyclopropanes
• Synthesis of dipyrromethanes
• Synthesis of halosulfates and sulfamoyl halides
• Synthesis of N-(benzoyloxy)amides
• Synthesis of N-(benzoyloxy)amines
• Synthesis of N-(benzoyloxy)carbamates and ureas
• Synthesis of N-(benzoyloxy)imides
• Synthesis of porphyrins
• Synthesis of triazoles via azide-nitrile cycloaddition

Version 24.0 of SYNTHIA™ has been tested with Chrome versions 120.0.6099.129, 120.0.6099.130, 120.0.6099.199, Microsoft Edge version 120.0.2210.91 on Windows 10 Enterprise, and Mac OS Ventura 13.6.3 and Sonoma 14.2.1.