Release 6.3 - March 2022

We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed.

3100 new expert rules have been added, covering reactions such as:

• Synthesis of 1-substituted 1,2,3-triazoles
• Aromatic Nucleophilic Substitution of Nitroanilines
• Asymmetric Synthesis of Protected Unnatural Alpha-amino Acids
• Copper-catalyzed Synthesis of 1,2,4-triazoles
• Cycloaddition of Propargylamines with Dialkyl Azodicarboxylates
• Decarboxylative Halogenations of Carboxylic Acids
• Glycosylation of Alcohols
• Metal-free Synthesis of 1-substituted-1,2,3-triazoles
• 1,3-directed Metalations Followed by Reactions with Electrophiles
• Protodecarboxylation of 1-aryl-4-fluoroalkyl-1,2,3-triazoles-5-carboxylic Acids
• Radical Hydroxymethylation of Alkyl Iodides
• Rhodium-catalyzed Regio- and Enantioselective Allylic Amination of Racemic 1,2-disubstituted Allylic Phosphates
• Silver-mediated Synthesis of 3-substituted Pyrazoles
• Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines
• Synthesis Aromatic Azoxy Compounds from Anilines
• Synthesis of [1,2,4]triazolo[1,5-a]pyridin-2-amines
• Visible-light-induced Decarboxylative Iodination of Aromatic Carboxylic Acids

The database of commercial compounds has been updated, to include:

• 821,078 new compounds
• 5,426,620 updated compounds
• For a total of 18,213,395 published compounds, including 6,897,424 commercial compounds

Version 6.2.0 of SYNTHIA™ has been tested with Chrome version 100.0.4896.60, 99.0.4844.84, 99.0.4844.83, 99.0.4844.82, 99.0.4844.51, 98.0.4758.109, 98.0.4758.102, 98.0.4758.80, and Edge version 99.0.1150.55, 99.0.1150.39, 98.0.1108.62, 98.0.1108.51, on Windows 10 version 1909, and Mac OS Monterey 12.2.