Release 5.5 - March 2021

We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed.

• Access our new Learning Center, where you can find training videos, detailed user manuals, and featured tips and tricks
• Improved search algorithm designed to increase diversity in your Automatic Retrosynthesis results

• Updated commercial compounds catalogs
• Improved search by name for target molecule
• Added support for non-Latin characters in inventory

1050 new expert rules have been added, covering reactions such as:

• Synthesis of pyridones from pyrones
• Asymmetric Simmons-Smith reaction
• Synthesis of 2-iminothiazolidin-4-ones
• Photoredox pentafluoroethylation of aryl bromides
• Synthesis of 1,2,4-triazoles
• Synthesis of alpha-oxoketene S,S-acetals
• [4+2] cyclization of ketene dithioacetals with acyl chlorides
• Ohira-Bestmann reaction
• Opening of 2H-cyclopenta[6]furanones with organocopper reagents
• Trifluoromethoxylation of aromatic diazonium salts
• Trifluoromethylation of phenols
• Asymmetric acyl-Strecker reaction

Version 5.5.0 of SYNTHIA™ has been tested with Chrome version 88.0.4324.182 on Windows 10, and Chrome versions 84.0.4147.89, 88.0.4324.150 and 88.0.4324.182 on Mac OS Catalina 10.15.7