Release 6.2 - October 2021

We are constantly working to improve your experience with SYNTHIA™ Retrosynthesis Software. Here is a summary of what has changed.

• Promote robust reactions in your results by enabling the new Robustness option in your analysis parameters
  
• Appoint an internal Account Manager to check user status, unlock users, or delete user accounts for your organization

• Improved performance decreases analyses run time

230 new expert rules have been added, covering reactions such as:

• Buchwald-Hartwig amination of nitroarenes
• Palladium-catalyzed denitrative Sonogashira-type cross-coupling of nitrobenzenes with terminal alkynes
• Diastereoselective Palladium-catalyzed hydrogenation of fluoropyridines
• Rhodium-catalyzed enantioselective hydroformylation of alkenes
• Intramolecular Copper-catalyzed Buchwald-Hartwig reaction
• Light-promoted stereoselective synthesis of unnatural alpha-amino acid derivatives
• Palladium-catalyzed hydrogenation of fluoropyridines and fluoroimidazopyridines
• Palladium-catalyzed Mizoroki-Heck reaction of nitroarenes and styrene derivatives
• Ritter reaction
• Stereospecific Suzuki-Miyaura cross-coupling forming diaryl quaternary stereocenters
• Suzuki-Miyaura coupling of nitroarenes
• Transition metal-catalyzed denitrative thioetherification of alkyl halides and arylboronic acids with nitroarenes
• Transition metal-catalyzed denitrative etherification of nitroarenes
• Transition metal-catalyzed denitrative methylation of nitroarenes

The database of commercial compounds has been updated, to include:

• 229,355 new compounds
• 4.78 million updated compounds
• For a total of 17,392,316 published compounds, including 7,014,712 commercial compounds

Version 6.2.0 of SYNTHIA™ has been tested with Chrome version 93.0.4577.82, 91.0.4472.124 and 91.0.4472.124 on Windows 10 version 1909, and Mac OS Catalina 10.15.7 and Big Sur 11.4 and 11.5.2.