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Learning Center
Do you know…
… how a Shared Path Library works?
Shared Path Library is a type of anlysis designed to find synthetic plans for libraries of analogue compounds.
You can enter a library of up to 20 target molecules and Synthia will analyze simultaneously all the submitted compounds to identify shared synthetic steps and intermediates between the pathways found for each compound.
Synthia will then prioritize pathways with the most shared synthetic steps and return three synthesis options for each target molecule. These results may help you find late-stage divergent syntheses for your library.
A Shared Path Library analysis is easy to set up. Use the Upload button in the analysis setup page to upload a file with your target molecules, saved in a compatible format, such as MOL file, SF file or CSV file (structures listed as SMILES in a column with a header titled ‘SMILES’).
Once the file is loaded, the Multiple-Target Analysis Setup page opens automatically. Your target molecules are displayed in a grid in the middle pane and ‘Shared Path Library’ is selected by default.
Just select your preferred analysis parameters and start the analysis.
The results are presented in Pathway View. The number of compounds in the library is displayed next to the library name, at the top of the results. Click on the Eye icon to see the structures of the target molecules in a popup window.
SYNTHIA™ returns three sets of pathways per library. Each set contains one pathway for each target molecule and highlights shared intermediates and reactions between the pathways in the set. The number of unique reactions and repeated intermediates for all the pathways in the set is displayed in the header of each set.
Starting materials and intermediates that are common to multiple pathways in a set are highlighted in a matching color box. The badge on the box indicates the number of pathways which use the molecule in the set. Similarly, reactions that are repeated in multiple pathways for a set are highlighted with matching color arrows, with a badge indicating the number of pathways using the reaction.
You can find your Shared Path Library on the home dashboard page as an analysis tile with a library image instead of a molecule structure. Click on the Eye icon to see the list of target molecules included in the library in a popup window.
For more information on Shared Path Library, you can search for ‘shared path’ in the Learning Center or contact our team at
